Methylphenidate's effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls.

ABSTRACT: Methylphenidate (MPH) is a first line treatment for ADHD and is also misused as a purported cognitive enhancer, yet its effects on brain function are still poorly understood. Recent functional magnetic resonance imaging (fMRI) studies showed that MPH altered cortico-striatal resting functional connectivity (RFC). Here we investigated the effects of MPH in thalamic connectivity since the thalamus modulates striato-cortical signaling. We hypothesized that MPH would increase thalamic connectivity and metabolism, and that this response would be blunted in cannabis abusers. For this purpose, we measured RFC in seven thalamic nuclei using fMRI and brain glucose metabolism using positron emission tomography (PET) and ¹⁸F-fluorodeoxyglucose (FDG) in sixteen healthy controls and thirteen

SUBMITTER: Demiral SB 

PROVIDER: S-EPMC6785138 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature