Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. To identify risk variants that are associated with gene expression in human brain and to identify genes whose expression change may contribute to the susceptibility of MDD, we systematically integrated the genetic associations from a large-scale MDD GWAS (N = 480,359) and brain expression quantitative trait loci (eQTL) data (N = 494) using a Bayesian statistical framework (Sherlock). Sherlock integrative analysis showed that FLOT1 was significant

SUBMITTER: Zhong J 

PROVIDER: S-EPMC6785150 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature