Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal.

ABSTRACT: The United States is experiencing an opioid crisis imposing enormous fiscal and societal costs and driving the staggering overdose death rate. While prescription opioid analgesics are essential for treating acute pain, cessation of use in individuals with a physical dependence induces an aversive withdrawal syndrome that promotes continued drug use to alleviate/avoid these symptoms. Additionally, repeated bouts of withdrawal often lead to an increased propensity for relapse. Understanding the neurobiology underlying withdrawal is essential for providing novel treatment options to alleviate physiological and affective components accompanying the cessation of opiate use. Here, we administered morphine and precipitated withdrawal with naloxone to investigate behavioral and cellular responses

SUBMITTER: Luster BR 

PROVIDER: S-EPMC6785353 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature