Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.

ABSTRACT:

Background

Red blood cell exchange (RCE) transfusions are a mainstay in the treatment of sickle cell anemia (SCA), and allow a temporary restoration of physiological parameters with respect to erythrocyte oxygen carrying capacity and systems metabolism. Recently, we noted that 1) RCE significantly impacts recipients' metabolism in SCA; 2) fresh and end-of-storage red blood cell (RBC) units differently impact systems of metabolism in healthy autologous recipients; and 3) phosphate/inosine/pyruvate/adenine (PIPA) solution reverses the metabolic age of stored RBCs. Therefore, we hypothesized that RCE with PIPA-treated RBC units could further increase the metabolic benefits of RCE in SCA patients.

Study design and methods

Circulating plasma and erythrocytes were collected from p

SUBMITTER: Gehrke S 

PROVIDER: S-EPMC6785363 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature