Full annotation of serum virome in Chinese blood donors with elevated alanine aminotransferase levels.

ABSTRACT:

Background

A serum alanine aminotransferase (ALT) test is currently demanded for blood donation in China. One of the major reasons to include such a test is possible etiology of known or unknown hepatotropic viruses. However, this hypothesis has never been examined convincingly.

Study design and methods

The study recruited 90 Chinese blood donors that were divided into three groups based on their ALT values. Serum virome from these donors was explored using a metagenomics approach with enhanced sensitivity resolved at single sequencing reads.

Results

Anellovirus and pegivirus C (GBV-C) were detected among these donors. None of them were found solely in donors with abnormal liver enzyme. Anellovirus was highly prevalent (93.3%) and the co-infection with multiple genera

SUBMITTER: Li G 

PROVIDER: S-EPMC6785372 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature