Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic.

ABSTRACT:

Background

Zika virus (ZIKV) spread to Puerto Rico likely originated from southeastern Brazil approximately 8.5 months earlier than blood donation screening for ZIKV was initiated, but the time of ZIKV introduction in the blood donor population remains unknown.

Methods

To better understand when arboviral infections first appeared in the blood donor pool in Puerto Rico, we retrospectively screened for ZIKV RNA (as well as chikungunya [CHIKV] and dengue [DENV] viral RNA) a repository of 1186 linked blood donor and recipient samples collected from February 2015 to May 2016 as an endpoint efficacy measure following the introduction of platelet pathogen reduction (PR). Phylogenetic analysis identified relatedness of donor strain to other circulating strains, and molecular clock a

SUBMITTER: Saa P 

PROVIDER: S-EPMC6785374 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature