Salience network connectivity is reduced by a meal and influenced by genetic background and hypothalamic gliosis.

ABSTRACT:

Background/objectives

The salience network (SN) comprises brain regions that evaluate cues in the external environment in light of internal signals. We examined the SN response to meal intake and potential genetic and acquired influences on SN function.

Subjects/methods

Monozygotic (MZ; 40 pairs) and dizygotic (15 pairs) twins had body composition and plasma metabolic profile evaluated (glucose, insulin, leptin, ghrelin, and GLP-1). Twins underwent resting-state functional magnetic resonance imaging (fMRI) scans before and after a standardized meal. The strength of SN connectivity was analyzed pre- and post-meal and the percentage change elicited by a meal was calculated. A multi-echo T2 MRI scan measured T2 relaxation time, a radiologic index of gliosis, in the mediobasal h

SUBMITTER: Sewaybricker LE 

PROVIDER: S-EPMC6785381 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature