NaHCO₃ Dilates Mouse Afferent Arteriole Via Na⁺/HCO₃^- Cotransporters NBCs.

ABSTRACT: Sodium bicarbonate has long been used to treat chronic kidney disease. It has been demonstrated to slow the decline in glomerular filtration rate in chronic kidney disease patient; however, the mechanisms are not completely understood. We hypothesized that NaHCO₃ dilates afferent arterioles (Af-Art) by stimulating nitric oxide (NO) release mediated by the Na⁺/HCO₃^- cotransporter (NBC) contributing to the elevation in glomerular filtration rate. Isolated microperfused mouse renal Af-Art, preconstricted with norepinephrine (1 µmol/L), dilated 45±2% (n=6, P<0.05) in response to NaHCO₃ (44 mmol/L). Whereas, NaCl solution containing the same Na⁺ concentration was not effective. The mRNA for NBCn1 and NBCe1 were detected in

SUBMITTER: Jiang S 

PROVIDER: S-EPMC6785401 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature