Association between an indel polymorphism within the distal promoter of EGLN2 and cancer risk: An updated meta-analysis.

ABSTRACT:

Background

The association between a 4-bp indel polymorphism (rs10680577) within the distal promoter of EGLN2 and cancer risk has been investigated by several case-control studies in recent years, but investigation results were inconsistent. Thus, a systematic assessment of the association was performed based on a literature review and pooled analysis.

Methods

Two investigators independently retrieved relevant studies from PubMed, Chinese National Knowledge Infrastructure (CNKI), Embase, and Google Scholar. The fixed or random effects model was selected to calculate odds ratios (ORs) with 95% confidence intervals (CIs) based on heterogeneity level. All analyses including heterogeneity assessment, subgroup analysis, sensitivity analysis, and publication bias assessment were p

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6785434 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature