TNF-α polymorphisms affect persistence and progression of HBV infection.

ABSTRACT:

Background

Hepatitis B virus (HBV) infections are a major threat worldwide. Disease progression and outcome is diverse and depends on host genetic background. Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor-α (TNF-α) antagonists showed the importance of this cytokine in HBV infection control. Here, we investigated the influence of TNF-α promoter polymorphisms on susceptibility to chronic HBV infection (CHB), liver injury progression and outcomes.

Methods

A total of 231 patients with CHB constituted the study group and 100 healthy volunteers-the local control group. TNF-α -1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A were genotyped using MALDI-TOF mass spectrometry.

Results

TNF-α -1031C and -863A alleles were observed more fr

SUBMITTER: Woziwodzka A 

PROVIDER: S-EPMC6785446 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature