Predictive testing for Huntington disease over 24 years: Evolution of the profile of the participants and analysis of symptoms.

ABSTRACT:

Background

Huntington disease (HD) is a devastating neurodegenerative autosomal dominant genetic condition. Predictive testing (PT) is available through a defined protocol for at-risk individuals. We analyzed the over-24-years evolution of practices regarding PT for HD in a single center.

Methods

We gathered data from the files of all individuals seeking PT for HD in Lyon, France, from 1994 to 2017.

Results

448 out of 567 participants had exploitable data. Age at consultation dichotomized over 24 years toward an eightfold increase in individuals aged >55 (2/94 vs. 30/183; 2% to 16%; p < .0001) and twice as many individuals aged 18-20 (3/94 vs. 12/183; 3%-7%; p < .05). Motives for testing remained stable. The rate of withdrawal doubled over 24 years (9/94 vs. 38/183; 9

SUBMITTER: Ramond F 

PROVIDER: S-EPMC6785454 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature