Relationships between [¹⁸F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia.

ABSTRACT:

Background and purpose

There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), the semantic variant (svPPA), and the logopenic variant (lvPPA). We sought to characterize the pattern of [¹⁸F]-THK5351 retention across all three subtypes and determine the topography of [¹⁸F]-THK5351 retention correlated with each neurolinguistic score.

Methods

We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, and 5 lvPPA) and 37 subjects with normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging, [¹⁸F]-THK5351 positron-emission tomography scans, and detailed neuropsychological tests. The PPA patients additionally participated in extensive neurolinguistic tests. Voxel-wise and region-of-intere

SUBMITTER: Jeong HJ 

PROVIDER: S-EPMC6785468 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature