CT and CEST MRI bimodal imaging of the intratumoral distribution of iodinated liposomes.

ABSTRACT:

Background

To develop liposomes loaded with iodinated agents as nanosized CT/MRI bimodal contrast agents for monitoring liposome-mediated drug delivery.

Methods

Rhodamine-labeled iodixanol (Visipaque^TM)-loaded liposomes (IX-lipo) were prepared and tested for their properties as a diamagnetic CEST contrast agent in vitro. Mice bearing subcutaneous CT26 colon tumors were injected i.v. with 1 g/kg (535 mg iodine/kg) IX-lipo, and in vivo CT and CEST MR images were acquired on day 3. CT and CEST MR images were also acquired for tumor-bearing mice co-injected with IX-lipo and tumor necrosis factor (TNF-α).

Results

In addition to CT contrast, IX-lipo exhibited a strong CEST contrast similar to its non-liposomal form, with a detectability of ~2 nM per

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6785501 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature