Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy.

ABSTRACT: Extracellular vesicles (EVs) are emerging as key players in intercellular communication. EVs can transfer biological macromolecules to recipient cells, modulating various physiological and pathological processes. It has been shown that tumor cells secrete large amounts of EVs that can be taken up by malignant and stromal cells, dictating tumor progression. In this study, we investigated whether EVs secreted by melanoma cells in response to chemotherapy modulate tumor response to alkylating drugs. Our findings showed that human and murine melanoma cells secrete more EVs after treatment with temozolomide and cisplatin. We observed that EVs shed by melanoma cells after temozolomide treatment modify macrophage phenotype by skewing macrophage activation towards the M2 phenotype through upregula

SUBMITTER: Andrade LNS 

PROVIDER: S-EPMC6785560 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature