Negative affect moderates the effect of social rejection on frontal and anterior cingulate cortex activation in borderline personality disorder.

ABSTRACT: Patients with borderline personality disorder (BPD) have a heightened sensitivity to social exclusion. Experimental manipulations have produced inconsistent findings and suggested that baseline negative affect (NA) might influence the experience of exclusion. We administered a standardized social exclusion protocol (Cyberball paradigm) in BPD (n = 39) and age-matched and sex-matched healthy controls (n = 29) to investigate the association of NA on social exclusion and activation in brain regions previously implicated in this paradigm. Compared with controls, patients with BPD showed higher activation during social exclusion in the anterior cingulate cortex (ACC), the medial prefrontal cortex (mPFC), and in the right precuneus. Prescan NA ratings were associated with higher brain activation

SUBMITTER: Wrege JS 

PROVIDER: S-EPMC6785570 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature