Closing the Gap Between Therapeutic Use and Mode of Action in Remedial Herbs.

ABSTRACT: The ancient tradition of taking parts of a plant or preparing plant extracts for treating certain discomforts and maladies has long been lacking a scientific rationale to support its preparation and still widespread use in several parts of the world. In an attempt to address this challenge, we collected and integrated data connecting metabolites, plants, diseases, and proteins. A mechanistic hypothesis is generated when a metabolite is known to be present in a given plant, that plant is known to be used to treat a certain disease, that disease is known to be linked to the function of a given protein, and that protein is finally known or predicted to interact with the original metabolite. The construction of plant-protein networks from mutually connected metabolites and diseases facilitated

SUBMITTER: Olives J 

PROVIDER: S-EPMC6785637 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature