Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood.

ABSTRACT: Chronic adolescent stress alters behavior in a sex-specific manner at the end of adolescence and in adulthood. Although prolonged behavioral repercussions of chronic adolescent stress have been documented, the potential underlying mechanisms are incompletely understood. In this study we demonstrate that a history of chronic adolescent stress modified the adult stress response, as measured by corticosterone concentration, such that a history of chronic adolescent stress resulted in a blunted response to a novel acute stressor. In order to begin to address potential mechanistic underpinnings, we assessed the extent to which chronic adolescent stress impacted global DNA methylation. Reduced global hippocampal methylation was evident in females with a history of chronic adolescent stress; thus

SUBMITTER: Rowson SA 

PROVIDER: S-EPMC6785712 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature