Bone Marrow Absorbed Doses and Correlations with Hematologic Response During ¹⁷⁷Lu-DOTATATE Treatments Are Influenced by Image-Based Dosimetry Method and Presence of Skeletal Metastases.

ABSTRACT: This study aimed to compare different image-based methods for bone marrow dosimetry and study the dose-response relationship during treatment with ¹⁷⁷Lu-DOTATATE in patients with and without skeletal metastases. Methods: This study included 46 patients with advanced neuroendocrine tumors treated with at least 2 fractions of ¹⁷⁷Lu-DOTATATE at Sahlgrenska University Hospital. High- and low-uptake compartments were automatically outlined in planar images collected at 2, 24, 48, and 168 h after injection. The bone marrow absorbed doses were calculated from the cross doses of the high- and low-uptake compartments and the self-dose, using the time-activity concentration curve for the low-uptake compartment. This time-activity concentration curve was adjusted using a

SUBMITTER: Hagmarker L 

PROVIDER: S-EPMC6785794 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature