Dynamic ¹¹C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis.

ABSTRACT: Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of brain homeostasis. ¹¹C-Pittsburgh compound B (PiB) PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer disease. The current study investigates the magnitude of ¹¹C-PiB PET signal in the lateral ventricles of an independent group of Alzheimer and mild cognitive impairment subjects. We have also evaluated multiple sclerosis as a model of disease with CSF clearance alterations without amyloid-β tissue accumulation. Methods: A set of 11 Alzheimer and 12 mild cognitive impairment subjects and a set of 20 multiple sclerosis subjects with matched controls underwent MRI and dynamic ¹¹C-PiB PET. Lateral ventricle regions of interest

SUBMITTER: Schubert JJ 

PROVIDER: S-EPMC6785797 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature