Benchmark datasets of immune receptor-epitope structural complexes.

ABSTRACT:

Background

The development of accurate epitope prediction tools is important in facilitating disease diagnostics, treatment and vaccine development. The advent of new approaches making use of antibody and TCR sequence information to predict receptor-specific epitopes have the potential to transform the epitope prediction field. Development and validation of these new generation of epitope prediction methods would benefit from regularly updated high-quality receptor-antigen complex datasets.

Results

To address the need for high-quality datasets to benchmark performance of these new generation of receptor-specific epitope prediction tools, a webserver called SCEptRe (Structural Complexes of Epitope-Receptor) was created. SCEptRe extracts weekly updated 3D complexes of antibody

SUBMITTER: Mahajan S 

PROVIDER: S-EPMC6785892 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature