Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p.

ABSTRACT:

Background

We aimed to investigate the correlation of Circ-SMARCA5 with disease severity and prognosis in multiple myeloma (MM), and its underlying mechanisms in regulating cell proliferation and apoptosis.

Methods

Bone marrow samples from 105 MM patients and 36 healthy controls were collected for Circ-SMARCA5 expression measurement. And the correlation of Circ-SMARCA5 expression with patients' characteristics and survival was determined. In vitro, the effect of Circ-SMARCA5 on MM cell proliferation and apoptosis was evaluated by altering Circ-SMARCA5 expression through transfection. Rescue experiments and luciferase assay were further performed to explore the mechanism of Circ-SMARCA5 as well as its potential target miR-767-5p in regulating MM cell activity.

Results

SUBMITTER: Liu H 

PROVIDER: S-EPMC6785934 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature