Suture dehiscence and collagen content in the human mitral and tricuspid annuli.

ABSTRACT: Postoperative suture dehiscence is an important mode of short-term mitral and tricuspid valve (MV, TV) repair failure. We sought to evaluate suture pullout forces and collagen density in human atrioventricular valves for a better understanding of the comparative physiology between the valves and the underlying mechanobiological basis for suture retention. Mitral and tricuspid annuli were each excised from hearts from human donors age 60-79 with no history of heart disease (n = 6). Anchor sutures were vertically pulled until tearing through the tissue. Suture pullout force (F_P) was measured as the maximum force at dehiscence. Subsequently, tissue samples from each tested suture position were evaluated for collagen content using a standard hydroxyproline assay. Among all mitral po

SUBMITTER: Madukauwa-David ID 

PROVIDER: S-EPMC6785974 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature