Diverse pathophysiological processes converge on network disruption in mania.

ABSTRACT:

Background

Neuroimaging of psychiatric disease is challenged by the difficulty of establishing the causal role of neuroimaging abnormalities. Lesions that cause mania present a unique opportunity to understand how brain network disruption may cause mania in both lesions and in bipolar disorder.

Methods

A literature search revealed 23 case reports with imaged lesions that caused mania in patients without history of bipolar disorder. We traced these lesions and examined resting-state functional Magnetic Resonance Imaging (rsfMRI) connectivity to these lesions and control lesions to find networks that would be disrupted specifically by mania-causing lesions. The results were then used as regions-of-interest to examine rsfMRI connectivity in patients with bipolar disorder (n = 1

SUBMITTER: Lee I 

PROVIDER: S-EPMC6785980 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature