Unknown

Dataset Information

0

Cardiovascular safety of linagliptin compared with other oral glucose-lowering agents in patients with type 2 diabetes: A sequential monitoring programme in routine care.


ABSTRACT: AIM:To evaluate the safety of linagliptin versus other glucose-lowering medications in a multi-year monitoring programme using insurance claims data. METHODS:In two commercial US claims databases, we identified three pairwise 1:1 propensity-score (PS)-matched cohorts of patients with type 2 diabetes (T2D) aged ?18?years initiating linagliptin or a comparator (other dipeptidyl peptidase-4 [DPP-4] inhibitors [n?=?31 492 pairs], pioglitazone [n?=?23 316 pairs], or second-generation sulphonylureas [n?=?19 731 pairs]) between May 2011 and December 2015. The primary endpoint was the risk of a composite cardiovascular (CV) outcome (hospitalization for myocardial infarction, stroke, unstable angina, or coronary revascularization). We estimated pooled hazard ratios (HRs) and 95% confidence intervals (CIs), controlling for >100 baseline characteristics. RESULTS:Patient characteristics were well balanced after PS-matching. The mean age was 55?years and mean follow-up was 0.8 years. Linagliptin conferred a similar risk of the composite CV outcome compared to other DPP-4 inhibitors (HR 0.91, 95% CI 0.79-1.05) and pioglitazone (HR 0.98, 95% CI 0.84-1.15), and showed a reduced risk of CV outcomes compared to second-generation sulphonylureas (HR 0.76, 95% CI 0.64--0.92). Key findings were signalled at the first interim analysis in June 2013 and solidified during ongoing monitoring until 2015. CONCLUSION:Analyses from a large monitoring programme in routine care of patients with T2D, showed that linagliptin had similar CV safety compared to other DPP-4 inhibitors and pioglitazone, and a reduced CV risk compared to sulphonylureas.

SUBMITTER: Patorno E 

PROVIDER: S-EPMC6785989 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cardiovascular safety of linagliptin compared with other oral glucose-lowering agents in patients with type 2 diabetes: A sequential monitoring programme in routine care.

Patorno Elisabetta E   Gopalakrishnan Chandrasekar C   Brodovicz Kimberly G KG   Meyers Andrea A   Bartels Dorothee B DB   Liu Jun J   Kulldorff Martin M   Schneeweiss Sebastian S  

Diabetes, obesity & metabolism 20190501 8


<h4>Aim</h4>To evaluate the safety of linagliptin versus other glucose-lowering medications in a multi-year monitoring programme using insurance claims data.<h4>Methods</h4>In two commercial US claims databases, we identified three pairwise 1:1 propensity-score (PS)-matched cohorts of patients with type 2 diabetes (T2D) aged ≥18 years initiating linagliptin or a comparator (other dipeptidyl peptidase-4 [DPP-4] inhibitors [n = 31 492 pairs], pioglitazone [n = 23 316 pairs], or second-generation s  ...[more]

Similar Datasets

| S-EPMC5934255 | biostudies-literature
| S-EPMC5487688 | biostudies-literature
| S-EPMC5483425 | biostudies-other
| S-EPMC9727535 | biostudies-literature
| S-EPMC8099964 | biostudies-literature
| S-EPMC6064594 | biostudies-literature
| S-EPMC8318034 | biostudies-literature
| S-EPMC8477618 | biostudies-literature
| S-EPMC8847873 | biostudies-literature
| S-EPMC7779275 | biostudies-literature