Preconception Leptin and Fecundability, Pregnancy, and Live Birth Among Women With a History of Pregnancy Loss.

ABSTRACT:

Context

With the increase of obesity, it is imperative to understand the neuroendocrine mechanisms, including the neuroendocrine hormone leptin, by which obese or overweight women are at increased risk for subfertility and infertility.

Objective

The objective was to examine associations between preconception serum leptin concentrations, fecundability, pregnancy, and live birth.

Design

Secondary analysis of a prospective cohort among women with prior pregnancy losses.

Setting

The study was conducted at four US medical centers (2006 to 2012).

Intervention

Not available.

Materials and methods

Preconception serum leptin concentrations were measured at baseline, and women were followed for up to six menstrual cycles, and throughout pregnancy if they co

SUBMITTER: Plowden TC 

PROVIDER: S-EPMC6786004 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature