Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice.

ABSTRACT: Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme of nicotinamide adenine dinucleotide (NAD) salvage biosynthesis in mammals, and is involved in fundamental physiological processes and pathophysiology of many diseases. Thus far, however, the role of Nampt in atherosclerosis development is still in debate. In this study, we crossed global Nampt transgenic mice (Nampt-Tg) with a well-established atherosclerosis animal model (ApoE knockout mice, ApoE^-/-) to generate ApoE^-/-;Nampt-Tg mice and investigated the effects of Nampt overexpression on atherosclerosis development in ApoE^-/- mice. Both ApoE^-/- and ApoE^-/-;Nampt-Tg mice were fed with a pro-atherosclerotic high-fat diet (HFD) for 16 weeks. Their serum lipid co

SUBMITTER: Kong YY 

PROVIDER: S-EPMC6786310 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature