Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A.

ABSTRACT: Understanding the dynamics of the immune response following late myocardial reperfusion is critical for the development of immunomodulatory therapy for myocardial infarction (MI). Cyclosporine A (CSA) possesses multiple therapeutic applications for MI, but its effects on the inflammation caused by acute MI are not clear. This study aimed to determine the dynamics of the immune response following myocardial ischemia/reperfusion (I/R) and the effects of CSA in a mouse model of prolonged myocardial ischemia designated to represent the human condition of late reperfusion. Adult C57BL/6 mice were subjected to 90 min of closed-chest myocardial I/R, which induced severe myocardial injury and excessive inflammation in the heart. Multicomponent analysis of the immune response caused by prolonged I/

SUBMITTER: Rusinkevich V 

PROVIDER: S-EPMC6786364 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature