Genetics of Adaptation of the Ascomycetous Fungus Podospora anserina to Submerged Cultivation.

ABSTRACT: Podospora anserina is a model ascomycetous fungus which shows pronounced phenotypic senescence when grown on solid medium but possesses unlimited lifespan under submerged cultivation. In order to study the genetic aspects of adaptation of P. anserina to submerged cultivation, we initiated a long-term evolution experiment. In the course of the first 4 years of the experiment, 125 single-nucleotide substitutions and 23 short indels were fixed in eight independently evolving populations. Six proteins that affect fungal growth and development evolved in more than one population; in particular, in the G-protein alpha subunit FadA, new alleles fixed in seven out of eight experimental populations, and these fixations affected just four amino acid sites, which is an unprecedented level of parallel

SUBMITTER: Kudryavtseva OA 

PROVIDER: S-EPMC6786475 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature