Differential Expression of Vascular Endothelial Growth Factor-A₁₆₅ Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease.

ABSTRACT:

Background

Vascular endothelial growth factor-A₁₆₅ (VEGF-A₁₆₅) has been identified as a combination of 2 alternative splice variants: proangiogenic VEGF-A₁₆₅a and antiangiogenic VEGF-A₁₆₅b. Intracranial atherosclerotic disease (ICAD) and moyamoya disease (MMD) are 2 main types of intracranial arterial steno-occlusive disorders with distinct capacities for collateral formation. Recent studies indicate that VEGF-A₁₆₅ regulates collateral growth in ischemia. Therefore, we investigated if there is a distinctive composition of VEGF-A₁₆₅ isoforms in ICAD and MMD.

Methods

Sixty-six ICAD patients, 6 MMD patients, and 5 controls were enrolled in this prospective study. ICAD and MMD patients received intensive medical m

SUBMITTER: Jiang H 

PROVIDER: S-EPMC6786492 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature