Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.

ABSTRACT:

Background

Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA dependence.

Methods

Participants (n = 106) with active MA dependence (MA-ACT), in remission from MA dependence (MA-REM), with active polysubstance dependence, in remission from polysubstance dependence, and with no history of substance dependence completed neuropsychiatric symptom questionnaires and provided blood samples. In vitro expression and function of CV and wild type TAAR1 receptors were also measured.

Results

The V288V polymorphism demonstrated a 40% increase in TAAR1 protein expression in cell

SUBMITTER: Loftis JM 

PROVIDER: S-EPMC6786581 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature