Diagnostic accuracy of midkine on hepatocellular carcinoma: A meta-analysis.

ABSTRACT:

Objective

To evaluate the dependability and accuracy of midkine (MK) in the diagnosis of hepatocellular carcinoma (HCC).

Methods

PubMed, EMBASE, Web of Science, China Biology Medicine disc and grey literature sources were searched from the date of database inception to January 2019. Two authors (B-H.Z. and B.L.) independently extracted the data and evaluated the study quality using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. The sensitivity, specificity, positive likelihood ratio (LR+) and negative likelihood ratio (LR-) were estimated using a bivariate model. Moreover, hierarchical summary receiver operating characteristic curves were generated. The diagnostic odds ratio (DOR) and area under the curve (AUC) were pooled using a univariate model.

Results<

SUBMITTER: Zhang BH 

PROVIDER: S-EPMC6786585 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature