A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage.

ABSTRACT: Malignant gliomas remain incurable with a poor prognosis despite of aggressive treatment. We have been studying the development of brain tumors in a glioma rat model, where rats develop brain tumors after prenatal exposure to ethylnitrosourea (ENU), and there is a sizable interval between when the first pathological changes are noted and tumors become detectable with MRI. Our aim to define a molecular timeline through proteomic profiling of the cerebrospinal fluid (CSF) such that brain tumor commitment can be revealed earlier than at the presymptomatic stage. A comparative proteomic approach was applied to profile CSF collected serially either before, at and after the time MRI becomes positive. Elastic net (EN) based models were developed to infer the timeline of normal or tumor developmen

SUBMITTER: Zheng L 

PROVIDER: S-EPMC6786640 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature