Opposing signaling pathways regulate morphology in response to temperature in the fungal pathogen Histoplasma capsulatum.

ABSTRACT: Phenotypic switching between 2 opposing cellular states is a fundamental aspect of biology, and fungi provide facile systems to analyze the interactions between regulons that control this type of switch. A long-standing mystery in fungal pathogens of humans is how thermally dimorphic fungi switch their developmental form in response to temperature. These fungi, including the subject of this study, Histoplasma capsulatum, are temperature-responsive organisms that utilize unknown regulatory pathways to couple their cell shape and associated attributes to the temperature of their environment. H. capsulatum grows as a multicellular hypha in the soil that switches to a pathogenic yeast form in response to the temperature of a mammalian host. These states can be triggered in the laboratory simpl

SUBMITTER: Rodriguez L 

PROVIDER: S-EPMC6786654 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature