Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts.

ABSTRACT:

Background

In patients with left heart failure, micro-RNAs (miRNAs) have been shown to be of diagnostic and prognostic value. The present study aims to identify those miRNAs in patients with univentricular heart (UVH) disease that may be associated with overt heart failure.

Methods

A large panel of human miRNA arrays were used to determine miRNA expression profiles in the blood of 48 UVH patients and 32 healthy controls. For further selection, the most abundantly expressed miRNA arrays were related to clinical measures of heart failure and selected miRNAs validated by polymerase chain reaction were used for the prediction of overt heart failure and all-cause mortality.

Results

According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH p

SUBMITTER: Abu-Halima M 

PROVIDER: S-EPMC6786722 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature