Bayesian Approach for Assessing Non-inferiority in Three-arm Trials for Risk Ratio and Odds Ratio.

ABSTRACT: In this paper we consider three-arm non-inferiority (NI) trial that includes an experimental, a reference, and a placebo arm. While for binary outcomes the risk difference (RD) is the most common and well explored functional form for testing efficacy (or effectiveness), recent FDA guideline suggested other measures such as relative risk (RR) and odds ratio (OR) on the basis of which NI of an experimental treatment can be claimed. However, developing test based on these different functions of binary outcomes are challenging since the construction and interpretation of NI margin for such functions are not trivial extensions of RD based approach. Recently, we have proposed Frequentist approaches for testing NI for these functionals. In this article we further develop Bayesian approaches for t

SUBMITTER: Chowdhury S 

PROVIDER: S-EPMC6786783 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature