Presynaptic Mitochondria Volume and Abundance Increase during Development of a High-Fidelity Synapse.

ABSTRACT: The calyx of Held, a large glutamatergic presynaptic terminal in the auditory brainstem undergoes developmental changes to support the high action-potential firing rates required for auditory information encoding. In addition, calyx terminals are morphologically diverse, which impacts vesicle release properties and synaptic plasticity. Mitochondria influence synaptic plasticity through calcium buffering and are crucial for providing the energy required for synaptic transmission. Therefore, it has been postulated that mitochondrial levels increase during development and contribute to the morphological-functional diversity in the mature calyx. However, the developmental profile of mitochondrial volumes and subsynaptic distribution at the calyx of Held remains unclear. To provide insight on t

SUBMITTER: Thomas CI 

PROVIDER: S-EPMC6786813 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature