Transverse relaxation of cerebrospinal fluid depends on glucose concentration.

ABSTRACT:

Purpose

To evaluate the biophysical processes that generate specific T₂ values and their relationship to specific cerebrospinal fluid (CSF) content.

Materials and methods

CSF T_2s were measured ex vivo (14.1T) from isolated CSF collected from human, rat and non-human primate. CSF T_2s were also measured in vivo at different field strength in human (3 and 7T) and rodent (1, 4.7, 9,4 and 11.7T) using different pulse sequences. Then, relaxivities of CSF constituents were measured, in vitro, to determine the major molecule responsible for shortening CSF T₂ (2s) compared to saline T₂ (3s). The impact of this major molecule on CSF T₂ was then validated in rodent, in vivo, by the simultaneous measurement of the major m

SUBMITTER: Daoust A 

PROVIDER: S-EPMC6786861 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature