Galectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane.

ABSTRACT: Galectin-3 (Gal-3) controls intercellular and cell-extracellular matrix interactions during immunological responses. In chronic inflammation, Gal-3 is associated with fibrotic events, regulates B cell differentiation and delays lupus progression. Gal-3 deficient mice (Lgals3^-/-) have intense germinal center formation and atypical plasma cell generation correlated to high levels IgG, IgE, and IgA. Here, we used pristane (2,6,10,14-tetramethylpentadecane) to induce lupus-like syndrome in Lgals3^-/- and Lgals3^+/+ BALB/c mice. Mesentery and peritoneal cells were monitored because promptly react to pristane injected in the peritoneal cavity. For the first time, mesenteric tissues have been associated to the pathogenesis of experimental lupus-like syndrome. In Lga

SUBMITTER: Lemos FS 

PROVIDER: S-EPMC6786989 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature