Heat shock protein 60 regulates yolk sac erythropoiesis in mice.

ABSTRACT: The yolk sac is the first site of blood-cell production during embryonic development in both murine and human. Heat shock proteins (HSPs), including HSP70 and HSP27, have been shown to play regulatory roles during erythropoiesis. However, it remains unknown whether HSP60, a molecular chaperone that resides mainly in mitochondria, could also regulate early erythropoiesis. In this study, we used Tie2-Cre to deactivate the Hspd1 gene in both hematopoietic and vascular endothelial cells, and found that Tie2-Cre⁺Hspd1^f/f (HSP60^CKO) mice were embryonic lethal between the embryonic day 10.5 (E10.5) and E11.5, exhibiting growth retardation, anemia, and vascular defects. Of these, anemia was observed first, independently of vascular and growth phenotypes. Reduced nu

SUBMITTER: Duan Y 

PROVIDER: S-EPMC6786998 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature