YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation.

ABSTRACT: Yes-associated protein (YAP) is a transcriptional co-factor involved in many cell processes, including development, proliferation, stemness, differentiation, and tumorigenesis. It has been described as a sensor of mechanical and biochemical stimuli that enables cells to integrate environmental signals. Although in the liver the correlation between extracellular matrix elasticity (greatly increased in the most of chronic hepatic diseases), differentiation/functional state of parenchymal cells and subcellular localization/activation of YAP has been previously reported, its role as regulator of the hepatocyte differentiation remains to be clarified. The aim of this study was to evaluate the role of YAP in the regulation of epithelial/hepatocyte differentiation and to clarify how a transducer

SUBMITTER: Noce V 

PROVIDER: S-EPMC6787001 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature