Human placental trophoblast cells contribute to maternal-fetal tolerance through expressing IL-35 and mediating iT_R35 conversion.

ABSTRACT: During pregnancy, trophoblast cells sustain the maternal-fetal tolerance via expressing and secreting various chemokines and cytokines. Our previous study revealed the expression of interleukin-35 (IL-35) in human first-trimester trophoblasts. Here we show that IL-35 is expressed in both human first-trimester primary trophoblast cells and a trophoblast cell line. Trophoblast cells inhibit the proliferation of human naive conventional T cells (T_conv cells) and convert suppressed T_conv cells into iT_R35 in an IL-35-dependent manner. Mechanistically, trophoblast cell derived IL-35 mediates its function through phosphorylation of STAT1 and STAT3. In vivo studies confirm that mice with immunologically spontaneous abortion have lower levels of IL-35 and iT_R</

SUBMITTER: Liu J 

PROVIDER: S-EPMC6787064 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature