Lowered anti-beta1 adrenergic receptor antibody concentrations may have prognostic significance in acute coronary syndrome.

ABSTRACT: Although several risk factors exist for acute coronary syndrome (ACS) no biomarkers for survival or risk of re-infarction have been validated. Previously, reduced serum concentrations of anti-ß₁AR Ab have been implicated in poorer ACS outcomes. This study further evaluates the prognostic implications of anti-ß₁AR-Ab levels at the time of ACS onset. Serum anti-ß₁AR Ab concentrations were measured in randomly selected patients from within the PLATO cohort. Stratification was performed according to ACS event: ST-elevation myocardial infarct (STEMI) vs. non-ST elevation myocardial infarct (NSTEMI). Antibody concentrations at ACS presentation were compared to 12-month all-cause and cardiovascular mortality, as well as 12-month re-infarction. Sub-analysis, strati

SUBMITTER: Ernst D 

PROVIDER: S-EPMC6787077 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature