Prion strain-dependent tropism is maintained between spleen and granuloma and relies on lymphofollicular structures.

ABSTRACT: In peripherally acquired prion diseases, prions move through several tissues of the infected host, notably in the lymphoid tissue, long before the occurrence of neuroinvasion. Accumulation can even be restricted to the lymphoid tissue without neuroinvasion and clinical disease. Several experimental observations indicated that the presence of differentiated follicular dendritic cells (FDCs) in the lymphoid structures and the strain type are critical determinants of prion extraneural replication. In this context, the report that granulomatous structures apparently devoid of FDCs could support prion replication raised the question of the requirements for prion lymphotropism. The report also raised the possibility that nonlymphoid tissue-tropic prions could actually target these inflammatory s

SUBMITTER: Al-Dybiat I 

PROVIDER: S-EPMC6787085 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature