Consciousness-specific dynamic interactions of brain integration and functional diversity.

ABSTRACT: Prominent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the brain. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and patients with disorders of consciousness, in order to identify consciousness-specific patterns of brain function. We demonstrate that cortical networks are especially affected by loss of consciousness during temporal states of high integration, exhibiting reduced functional diversity and compromised informational capacity, whereas thalamo-cortical functional disconnections emerge during states of higher segregation. Spatially, posterior regions of the brain's

SUBMITTER: Luppi AI 

PROVIDER: S-EPMC6787094 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature