Impaired Fine Motor Function of the Asymptomatic Hand in Unilateral Parkinson's Disease.

ABSTRACT: The early detection of Parkinson's disease (PD) still remains a challenge to date. Although studies have previously reported subtle motor function abnormalities in early PD patients, it is unclear whether such clinical signs can be better detected while patients are concurrently performing a cognitive task, and whether they can be useful in predicting patients' clinical conversion state. Seventy-two right-handed participants (40 drug-naive patients with idiopathic unilateral PD and 32 age-matched healthy controls) were enrolled in this study. All participants were asked to perform the Purdue Pegboard test (PPT) either alone (single-task condition) or during a concurrent mental subtraction-by-3 task (dual-task condition). A 4-year telephone follow-up was later conducted to determine whether

SUBMITTER: Dan X 

PROVIDER: S-EPMC6787142 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature