Engineering transferrable microvascular meshes for subcutaneous islet transplantation.

ABSTRACT: The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development of a broadly applicable strategy for stable and functional vascularization has remained challenging. We report here highly organized and resilient microvascular meshes fabricated through a controllable anchored self-assembly method. The microvascular meshes are scalable to centimeters, almost free of defects and transferrable to diverse substrates, ready for transplantation. They promote formation of functional blood vessels, with a density as high as ~220 vessels mm^-2, in the poorly vascularized subcutaneous space of SCID-Beige mice. We further demonstrate the feasibility of fabricating microvascular meshes from human induced plur

SUBMITTER: Song W 

PROVIDER: S-EPMC6787187 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature