Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis.

ABSTRACT: Extracellular vesicles (EVs) are involved in cell-to-cell communication and modulation of numerous physiological and pathological processes. EVs are found in large quantities in milk and contain several inflammation- and immunity-modulating proteins and microRNAs, through which they exert beneficial effects in several inflammatory disease models. Here, we investigated the effects of two EV subsets, concentrated from commercial cow's milk, on a murine model of colitis induced with dextran sodium sulfate (DSS). P35K EVs, isolated by ultracentrifugation at 35,000 g, and P100K EVs, isolated at 100,000 g, were previously characterized and administered by gavage to healthy and DSS-treated mice. P35K EVs and, to a lesser extent, P100K EVs improved several outcomes associated to DSS-induced coliti

SUBMITTER: Benmoussa A 

PROVIDER: S-EPMC6787204 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature