Additional Expiratory Resistance Elevates Airway Pressure and Lung Volume during High-Flow Tracheal Oxygen via Tracheostomy.

ABSTRACT: The standard high-flow tracheal (HFT) interface was modified by adding a 5-cm H₂O/L/s resistor to the expiratory port. First, in a test lung simulating spontaneous breathing, we found that the modified HFT caused an elevation in airway pressure as a power function of flow. Then, three tracheal oxygen treatments (T-piece oxygen at 10 L/min, HFT and modified HFT at 40 L/min) were delivered in a random crossover fashion to six tracheostomized pigs before and after the induction of lung injury. The modified HFT induced a significantly higher airway pressure compared with that in either T-piece or HFT (p < 0.001). Expiratory resistance significantly increased during modified HFT (p < 0.05) to a mean value of 4.9 to 6.7 cm H₂O/L/s. The modified HFT induced significant augme

SUBMITTER: Chen GQ 

PROVIDER: S-EPMC6787229 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature