Light-induced Nrf2^-/- mice as atrophic age-related macular degeneration model and treatment with nanoceria laden injectable hydrogel.

ABSTRACT: Elevated oxidative stress and associated reactive oxygen species (ROS) accumulation are hallmarks in the induction and progression of age-related macular degeneration (AMD). By exposing nuclear factor erythroid 2-related factor (Nrf2) knockout (Nrf2^-/-) mice to mild white light, we were able to generate a new dry-AMD like murine model to the study. This animal model developed phenotypes of photoreceptor degeneration, retinal function impairment, ROS accumulation, and inflammation reaction in a relatively shorter time. In the treatment of this animal model we utilized an antioxidative and water soluble nanoparticle known as glycol chitosan coated cerium oxide nanoparticles (GCCNP). The delivery of GCCNP protected retina against progressive retinal oxidative damage. Further combin

SUBMITTER: Wang K 

PROVIDER: S-EPMC6787253 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature