Inoculation Pneumonia Caused by Coagulase Negative Staphylococcus.

ABSTRACT:

Rationale

Although frequently retrieved in tracheal secretions of critically ill patients on mechanical ventilation, the existence of pneumonia caused by coagulase-negative staphylococci (CoNS) remains controversial.

Objective

To assess whether Staphylococcus haemolyticus (S. haemolyticus) inoculated in mice's trachea can infect normal lung parenchyma, increasing concentrations of S. haemolyticus were intratracheally administered in 221 immunocompetent mice.

Methods

Each animal received intratracheally phosphate-buffered saline (PBS) (n = 43) or live (n = 141) or inactivated (n = 37) S. haemolyticus at increasing load: 1.0 × 10⁶, 1.0 × 10⁷, and 1.0 × 10⁸ colony forming units (CFU). Forty

SUBMITTER: Shi MM 

PROVIDER: S-EPMC6787291 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature